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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:33234
Term: vitamin E
Definition: Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2multiple interactionsEXP 6480464CTDVitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]PMID:11163531 PMID:23114885
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTD[Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Vitamin E affects the reaction [Ethanol affects the activity of SOD2 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Vitamin E promotes the reaction [Thyroxine results in increased expression of SOD2 protein]PMID:10787391 PMID:18779489 PMID:19914224
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