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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2decreases activityEXP 6480464CTDresveratrol analog results in decreased activity of SOD2 proteinPMID:24398169
SOD2decreases expressionEXP 6480464CTDresveratrol analog results in decreased expression of SOD2 mRNA; resveratrol results in decreased expression of SOD2 mRNAPMID:21371465 PMID:24398169
SOD2increases activityEXP 6480464CTDresveratrol results in increased activity of SOD2 proteinPMID:23456297
SOD2increases expressionEXP 6480464CTDresveratrol results in increased expression of SOD2; resveratrol results in increased expression of SOD2 mRNA; resveratrol results in increased expression of SOD2 proteinPMID:17261084 PMID:20610621 PMID:21215799 PMID:22902249 PMID:24582596 PMID:24812624 PMID:25065674 PMID:26443543
SOD2increases response to substanceEXP 6480464CTDSOD2 protein results in increased susceptibility to resveratrolPMID:21215799
SOD2multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Resveratrol results in increased expression of SOD2 protein]; PRKN gene mutant form inhibits the reaction [Resveratrol results in increased expression of SOD2 mRNA]; Resveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein]; Resveratrol inhibits the reaction [Acrolein results in increased expression of SOD2 protein]; Resveratrol inhibits the reaction [HDAC5 protein binds to SOD2 promoter]; Resveratrol inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of SOD2 protein]; Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]; Resveratrol promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]; Resveratrol promotes the reaction [KLF2 protein binds to SOD2 promoter]; Resveratrol results in increased expression of and results in increased activity of SOD2 protein; SIRT3 mutant form inhibits the reaction [Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]]PMID:10942521 PMID:22902249 PMID:23452621 PMID:24008411 PMID:24361291 PMID:24557422 PMID:24582596 PMID:25065674 PMID:25472572 PMID:25522270 PMID:26443543
SOD2affects expressionISOSod2 (Rattus norvegicus)6480464CTDresveratrol affects the expression of SOD2 mRNAPMID:15748624
SOD2affects response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 protein affects the susceptibility to resveratrolPMID:23526725
SOD2decreases expressionISOSod2 (Mus musculus)6480464CTDresveratrol results in decreased expression of SOD2 proteinPMID:25505154
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of SOD2 proteinPMID:21666113
SOD2decreases metabolic processingISOSod2 (Mus musculus)6480464CTDresveratrol results in decreased metabolism of SOD2 proteinPMID:21270273
SOD2increases activityISOSod2 (Mus musculus)6480464CTDresveratrol results in increased activity of SOD2 proteinPMID:21270273 PMID:21454355
SOD2increases activityISOSod2 (Rattus norvegicus)6480464CTDresveratrol results in increased activity of SOD2 proteinPMID:19303434
SOD2increases expressionISOSod2 (Mus musculus)6480464CTDresveratrol results in increased expression of SOD2; resveratrol results in increased expression of SOD2 mRNA; resveratrol results in increased expression of SOD2 proteinPMID:19656070 PMID:20542495 PMID:20610621 PMID:21215799 PMID:21224254 PMID:22878646 PMID:23090186 PMID:23124026 PMID:23526725 PMID:24040102 PMID:24361291 PMID:25394648
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDresveratrol results in increased expression of SOD2 mRNA; resveratrol results in increased expression of SOD2 protein; resveratrol results in increased expression of SOD2 protein alternative formPMID:17401679 PMID:23786522 PMID:23891692 PMID:24040102 PMID:25544172 PMID:25895148
SOD2increases response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 protein results in increased susceptibility to resveratrolPMID:20542495
SOD2multiple interactionsISOSod2 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of SOD2 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of SOD2]; [Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA; [Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein; [resveratrol co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; [resveratrol co-treated with Excitatory Amino Acid Agents] results in increased expression of SOD2 protein; CTNNB1 protein promotes the reaction [resveratrol results in increased expression of SOD2 protein]; ESR2 gene mutant form inhibits the reaction [resveratrol results in increased expression of SOD2 protein]; ESR2 protein affects the reaction [resveratrol results in increased expression of SOD2 protein]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]; FOXO1 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]; FOXO3 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 mRNA]; FOXO4 mutant form affects the reaction [[Antimycin A co-treated with resveratrol] affects the expression of SOD2 protein]; fulvestrant inhibits the reaction [resveratrol results in increased expression of SOD2 protein]; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein]; resveratrol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; resveratrol inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; resveratrol inhibits the reaction [Isoflurane results in decreased activity of SOD2 protein]; resveratrol inhibits the reaction [Nicotine results in decreased expression of SOD2 protein]; resveratrol inhibits the reaction [stearic acid results in decreased expression of SOD2 mRNA]; resveratrol inhibits the reaction [Titanium results in decreased expression of SOD2 mRNA]; SOD2 protein promotes the reaction [resveratrol results in decreased susceptibility to Excitatory Amino Acid Agents]PMID:17374693 PMID:20542495 PMID:21215799 PMID:22687363 PMID:23090186 PMID:23124026 PMID:23293585 PMID:23526725 PMID:23695218 PMID:23922164 PMID:24040102 PMID:24361291 PMID:26878849 PMID:27260466
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTDNiacinamide inhibits the reaction [Resveratrol results in increased expression of SOD2 mRNA]; Resveratrol analog inhibits the reaction [bisphenol A results in decreased expression of SOD2 mRNA]; Resveratrol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of SOD2 mRNA]; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of SOD2 protein]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased expression of SOD2 protein]; Resveratrol results in increased expression of and results in increased activity of SOD2 proteinPMID:16366677 PMID:20861279 PMID:23891692 PMID:25905778 PMID:26955731 PMID:34067838 PMID:35024197
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