Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	730870
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CYP1A1
Name:	cytochrome P450 family 1 subfamily A member 1

Acc ID:	CHEBI:3647
Term:	chlorpromazine
Definition:	A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID:	MESH:D002746

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CYP1A1	decreases activity	EXP		6480464	CTD	Chlorpromazine results in decreased activity of CYP1A1 protein	PMID:33814510
CYP1A1	decreases response to substance	EXP		6480464	CTD	CYP1A1 protein results in decreased susceptibility to Chlorpromazine	PMID:26477383
CYP1A1	multiple interactions	EXP		6480464	CTD	[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]	PMID:18493746 PMID:29724254
CYP1A1	increases expression	ISO	Cyp1a1 (Rattus norvegicus)	6480464	CTD	Chlorpromazine results in increased expression of CYP1A1 mRNA	PMID:17202759 PMID:18246545 PMID:25596134
CYP1A1	multiple interactions	ISO	Cyp1a1 (Rattus norvegicus)	6480464	CTD	Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]	PMID:18493746

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