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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730870
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A1
Name: cytochrome P450 family 1 subfamily A member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A1affects expressionEXP 6480464CTDbisphenol A affects the expression of CYP1A1 mRNAPMID:20170705 PMID:30903817
CYP1A1decreases activityEXP 6480464CTDbisphenol A results in decreased activity of CYP1A1 proteinPMID:34181028
CYP1A1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CYP1A1 mRNA; bisphenol A results in decreased expression of CYP1A1 proteinPMID:16474171 PMID:23019147 PMID:33258555 PMID:36466761
CYP1A1increases expressionEXP 6480464CTDbisphenol A analog results in increased expression of CYP1A1 mRNA; bisphenol A results in increased expression of CYP1A1; bisphenol A results in increased expression of CYP1A1 mRNA; bisphenol A results in increased expression of CYP1A1 proteinPMID:16474171 PMID:25619500 PMID:26196221 PMID:31207516 PMID:31374317 PMID:32244372 PMID:32387340
CYP1A1increases response to substanceEXP 6480464CTDCYP1A1 protein results in increased susceptibility to bisphenol APMID:35395335
CYP1A1multiple interactionsEXP 6480464CTD3'-methoxy-4'-nitroflavone inhibits the reaction [bisphenol A results in increased expression of CYP1A1 mRNA]; [bisphenol A co-treated with cylindrospermopsin] results in decreased expression of CYP1A1 mRNA; [bisphenol A co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [cylindrospermopsin co-treated with bisphenol A] results in increased expression of CYP1A1 mRNAPMID:23524099 PMID:26196221 PMID:32244372
CYP1A1affects expressionISOCyp1a1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of CYP1A1 mRNAPMID:32145629
CYP1A1decreases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of CYP1A1 mRNAPMID:25181051
CYP1A1increases expressionISOCyp1a1 (Mus musculus)6480464CTDbisphenol A results in increased expression of CYP1A1 mRNA; bisphenol A results in increased expression of CYP1A1 proteinPMID:16284450 PMID:34585602
CYP1A1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of CYP1A1 mRNAPMID:35192832
CYP1A1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] results in increased expression of CYP1A1 mRNA; bisphenol A inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CYP1A1 mRNA]; bisphenol A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:11061999 PMID:23756648
CYP1A1multiple interactionsISOCyp1a1 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Dietary Fats] results in increased expression of CYP1A1 mRNAPMID:31489946
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