GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SOD1 | affects binding | EXP | | 6480464 | CTD | Glucose binds to SOD1 protein mutant form | PMID:12626432 | SOD1 | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of SOD1 mRNA | PMID:31655124 PMID:32942007 | SOD1 | decreases metabolic processing | EXP | | 6480464 | CTD | SOD1 protein mutant form results in decreased metabolism of Glucose | PMID:29419416 | SOD1 | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of SOD1 protein; Acetylcysteine inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]; CAT inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]; Glucose deficiency results in decreased expression of and results in increased degradation of SOD1 protein; Glucose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]; lactacystin inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]; SOD1 protein inhibits the reaction [Glucose results in increased expression of NOS2 mRNA]; SOD1 protein inhibits the reaction [Glucose results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Glucose deficiency results in decreased expression of and results in increased degradation of SOD1 protein]; U 0126 inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein] | PMID:12626432 PMID:17309078 PMID:22425406 PMID:28400208 | SOD1 | decreases expression | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased expression of SOD1 mRNA | PMID:21818840 | SOD1 | increases expression | ISO | Sod1 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of SOD1 protein | PMID:23090186 | SOD1 | increases expression | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of SOD1 mRNA | PMID:23192364 | SOD1 | multiple interactions | ISO | Sod1 (Mus musculus) | 6480464 | CTD | copper bis(3,5-diisopropylsalicylate) inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; NFKB1 protein inhibits the reaction [SOD1 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTGS2 protein]]; resveratrol inhibits the reaction [Glucose results in decreased expression of SOD1 protein]; SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]; SOD1 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased activity of NFKB1 protein]; SOD1 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK1 protein]; SOD1 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK3 protein]; SOD1 protein promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] | PMID:16395278 PMID:19228841 PMID:23090186 PMID:23795780 | SOD1 | multiple interactions | ISO | Sod1 (Rattus norvegicus) | 6480464 | CTD | [Glucose co-treated with Palmitic Acid] results in decreased expression of SOD1 protein; [Oxygen co-treated with Glucose] promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SOD1 protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SOD1 protein; naringenin inhibits the reaction [Glucose results in increased expression of SOD1 mRNA]; SOD1 protein inhibits the reaction [[INS1 protein co-treated with Glucose] results in increased activity of PARP1 protein] | PMID:18545258 PMID:23061969 PMID:23192364 PMID:28027979 | | ||||||||||||||||||||||
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