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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1affects bindingEXP 6480464CTDFructose binds to SOD1 protein mutant formPMID:12626432
SOD1multiple interactionsEXP 6480464CTDFructose promotes the reaction [SOD1 protein mutant form results in increased chemical synthesis of Hydrogen Peroxide]PMID:12626432
SOD1decreases activityISOSod1 (Rattus norvegicus)6480464CTDFructose results in decreased activity of SOD1 proteinPMID:16815490
SOD1decreases expressionISOSod1 (Rattus norvegicus)6480464CTDFructose results in decreased expression of SOD1 mRNA; Fructose results in decreased expression of SOD1 proteinPMID:11817707 PMID:20470786 PMID:21781943
SOD1increases activityISOSod1 (Rattus norvegicus)6480464CTDFructose results in increased activity of SOD1 proteinPMID:16815490
SOD1multiple interactionsISOSod1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in decreased expression of SOD1 proteinPMID:37271273
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTD[Fructose co-treated with Copper deficiency] results in decreased expression of SOD1 proteinPMID:21781943
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