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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1decreases activityEXP 6480464CTDRotenone results in decreased activity of SOD1 proteinPMID:30141137
SOD1increases expressionEXP 6480464CTDRotenone results in increased expression of SOD1 mRNA; Rotenone results in increased expression of SOD1 proteinPMID:32092105
SOD1multiple interactionsEXP 6480464CTD[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; [Rosiglitazone co-treated with Rotenone] results in increased expression of SOD1 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD1 protein]; geraniol inhibits the reaction [Rotenone results in decreased activity of SOD1 protein]PMID:24374061 PMID:30141137 PMID:32092105
SOD1decreases activityISOSod1 (Mus musculus)6480464CTDRotenone results in decreased activity of SOD1 proteinPMID:32937126
SOD1decreases activityISOSod1 (Rattus norvegicus)6480464CTDRotenone results in decreased activity of SOD1 proteinPMID:28532211 PMID:35337893
SOD1decreases expressionISOSod1 (Mus musculus)6480464CTDRotenone results in decreased expression of SOD1 mRNA; Rotenone results in decreased expression of SOD1 proteinPMID:17657281 PMID:35919817
SOD1decreases expressionISOSod1 (Rattus norvegicus)6480464CTDRotenone results in decreased expression of SOD1 mRNAPMID:21807080 PMID:30472438
SOD1increases expressionISOSod1 (Mus musculus)6480464CTDRotenone results in increased expression of SOD1 mRNAPMID:30099449
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDRotenone results in increased expression of SOD1 mRNA; Rotenone results in increased expression of SOD1 proteinPMID:17079513 PMID:35544339
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTD1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea inhibits the reaction [Rotenone results in decreased expression of SOD1 mRNA]; 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [[Docosahexaenoic Acids co-treated with Rotenone] results in increased expression of SOD1 mRNA]; [Docosahexaenoic Acids co-treated with Rotenone] results in increased expression of SOD1 mRNA; Catechin inhibits the reaction [Rotenone results in decreased activity of SOD1 protein]; Quercetin analog inhibits the reaction [Rotenone results in increased expression of SOD1 mRNA]; Quercetin inhibits the reaction [Rotenone results in decreased activity of SOD1 protein]; Quercetin inhibits the reaction [Rotenone results in increased expression of SOD1 mRNA]PMID:17070561 PMID:17079513 PMID:30472438 PMID:33279658 PMID:35337893
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