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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1increases activityEXP 6480464CTDTetrachlorodibenzodioxin results in increased activity of SOD1 proteinPMID:11589571
SOD1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SOD1 mRNAPMID:11589571 PMID:12487371
SOD1multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOD1 promoter]PMID:11589571
SOD1affects expressionISOSod1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SOD1 mRNAPMID:21570461
SOD1decreases expressionISOSod1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SOD1 mRNAPMID:18467041 PMID:28213091
SOD1decreases expressionISOSod1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SOD1 mRNAPMID:12225545
SOD1increases expressionISOSod1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SOD1 mRNAPMID:28836330
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SOD1 mRNA; Tetrachlorodibenzodioxin results in increased expression of SOD1 proteinPMID:12361703 PMID:32387183 PMID:33387578
SOD1multiple interactionsISOSod1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOD1 gene]PMID:28213091
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