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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased activity of SOD1 protein; [Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of SOD1 mRNA; [Estradiol deficiency co-treated with Medroxyprogesterone Acetate deficiency] results in decreased activity of SOD1 protein; [Estradiol deficiency co-treated with Medroxyprogesterone Acetate deficiency] results in decreased expression of SOD1 mRNA; Estradiol promotes the reaction [Medroxyprogesterone Acetate results in increased activity of SOD1 protein]PMID:11756571 PMID:12093828
SOD1increases activityISOSod1 (Rattus norvegicus)6480464CTDEstradiol results in increased activity of SOD1 proteinPMID:15820610 PMID:21966433
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTD[Progesterone co-treated with Estradiol] results in increased activity of SOD1 protein; Estradiol affects the reaction [Paraquat affects the expression of SOD1 protein]; Estradiol inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein]; Tamoxifen inhibits the reaction [Estradiol results in increased activity of SOD1 protein]PMID:14659978 PMID:15820610 PMID:21966433 PMID:31715309
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