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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730847
Species: Mus musculus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases expressionISOCasp8 (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of CASP8 mRNA; Isoproterenol results in increased expression of CASP8 proteinPMID:25794854 PMID:26996544 PMID:30152906 PMID:34816538
Casp8multiple interactionsISOCasp8 (Rattus norvegicus)6480464CTDApigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; caryophyllene inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]; Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]PMID:25794854 PMID:26996544 PMID:30152906 PMID:34816538
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