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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730847
Species: Mus musculus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein; pifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; TP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]PMID:19728331
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