GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 127284846 | RGD | N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP8 protein in the stomach) | | Casp8 | multiple interactions | EXP | | 6480464 | CTD | [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 protein]]; Acetylcysteine inhibits the reaction [cannabidiol hydroxyquinone results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein] | PMID:20184945 PMID:20576514 PMID:20883752 PMID:24614525 PMID:29432840 PMID:35833596 | Casp8 | multiple interactions | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]; [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP8 protein] | PMID:18791325 PMID:19477266 PMID:20946910 PMID:25845326 PMID:27484784 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP8 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased activity of and results in increased cleavage of CASP8 protein] | PMID:16169029 PMID:17574045 PMID:19014919 PMID:20674558 PMID:21310227 PMID:22578287 PMID:23711929 PMID:23867903 PMID:25034532 PMID:27313093 PMID:28087840 PMID:28219700 PMID:28548367 PMID:28918123 PMID:30917517 PMID:32506763 PMID:32662599 | | ||||||||||||||||||||||
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