GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | decreases expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Selenium results in decreased expression of CASP8 mRNA | PMID:19244175 | Casp8 | increases activity | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Selenium results in increased activity of CASP8 protein | PMID:12432279 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with Selenium] promotes the reaction [FADD protein binds to CASP8 protein]; [Doxorubicin co-treated with Selenium] promotes the reaction [FAS protein binds to CASP8 protein]; Selenium analog inhibits the reaction [Diazinon results in increased expression of CASP8 mRNA] | PMID:17970047 PMID:27920530 | |
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