GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases activity | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased activity of CASP8 protein | PMID:18291569 PMID:18436364 | Casp8 | increases cleavage | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased cleavage of CASP8 protein | PMID:25432964 | Casp8 | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of CASP8 protein | PMID:24530446 | Casp8 | multiple interactions | EXP | | 6480464 | CTD | 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]; Changkil inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein]; PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]; SC 560 promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein] | PMID:18291569 PMID:18436364 PMID:24530446 PMID:25432964 | Casp8 | increases activity | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased activity of CASP8 protein | PMID:12388182 | Casp8 | multiple interactions | ISO | Casp8 (Rattus norvegicus) | 6480464 | CTD | Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein] | PMID:12388182 | | ||||||||||||||||||||||
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