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GENE - TERM ANNOTATION REPORT

RGD ID: 730840
Species: Homo sapiens
RGD Object: Gene
Symbol: GRK3
Name: G protein-coupled receptor kinase 3
Acc ID: GO:0002029
Term: desensitization of G protein-coupled receptor signaling pathway
Definition: The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Definition Source(s): PMID:8396717
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GRK3 ISOGrk3 (Rattus norvegicus)9068941RGD PMID:20837135 PMID:8381966 REF_RGD_ID:5685022 REF_RGD_ID:5685621
GRK3involved_inIBAMGI:87940 or PANTHER:PTN008614780 or Grk2 (Rattus norvegicus) or Grk3 (Rattus norvegicus) or UniProtKB:P21146 or UniProtKB:P25098150520179GO_Central GO_REF:0000033
GRK3involved_inIEAPANTHER:PTHR24355:SF17150520179TreeGrafter GO_REF:0000118
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