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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730835
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1b7
Name: aldo-keto reductase family 1, member B7
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b7increases expressionEXP 6480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of AKR1B7 mRNA

PMID:20005886, PMID:21851831
Akr1b7multiple interactionsEXP 6480464CTD[2, 4, 4'-trichlorobiphenyl co-treated with 2, 5, 2', 5'-tetrachlorobiphenyl co-treated with 2, 4, 5, 2', 5'-pentachlorobiphenyl co-treated with 2, 2', 3', 4, 4', 5-hexachlorobiphenyl co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKR1B7 mRNA, Tetrachlorodibenzodioxin inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of AKR1B7 mRNA]

PMID:21851831, PMID:25510870
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.