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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730832
Species: Homo sapiens
RGD Object: Gene
Symbol: BMP4
Name: bone morphogenetic protein 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BMP4increases expressionEXP 6480464CTDValproic Acid results in increased expression of BMP4 mRNAPMID:23179753 PMID:24383497 PMID:26272509 PMID:28001369
BMP4multiple interactionsEXP 6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP4 mRNAPMID:27188386
BMP4increases expressionISOBmp4 (Mus musculus)6480464CTDValproic Acid results in increased expression of BMP4 mRNAPMID:19136453 PMID:34537371
BMP4increases expressionISOBmp4 (Rattus norvegicus)6480464CTDValproic Acid results in increased expression of BMP4 mRNAPMID:23562654 PMID:29427782
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