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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730826
Species: Homo sapiens
RGD Object: Gene
Symbol: ESRRA
Name: estrogen related receptor alpha
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESRRAaffects expressionEXP 6480464CTDEstradiol affects the expression of ESRRA mRNAPMID:22574217
ESRRAdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of ESRRA mRNAPMID:15968320
ESRRAincreases expressionEXP 6480464CTDEstradiol results in increased expression of ESRRA mRNA; Estradiol results in increased expression of ESRRA proteinPMID:15223131 PMID:20211987 PMID:23019147 PMID:31614463 PMID:32030086
ESRRAmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]; [Estradiol co-treated with TGFB1 protein] results in decreased expression of ESRRA mRNA; Dinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]; ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]; GPER1 protein promotes the reaction [Estradiol results in increased expression of ESRRA mRNA]; Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]PMID:15968320 PMID:20211987 PMID:20351196 PMID:30165855
ESRRAdecreases expressionISOEsrra (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of ESRRA mRNAPMID:15458797
ESRRAincreases expressionISOEsrra (Rattus norvegicus)6480464CTDEstradiol results in increased expression of ESRRA mRNAPMID:12193582 PMID:15458797
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