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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730823
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
Acc ID: CHEBI:61057
Term: tacrolimus hydrate
Definition: A hydrate that is the monohydrate form of tacrolimus.
Chemical ID: MESH:D016559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB1affects exportEXP 6480464CTDABCB1 protein affects the export of TacrolimusPMID:15919446 PMID:15964336
ABCB1affects response to substanceEXP 6480464CTDABCB1 protein affects the susceptibility to TacrolimusPMID:15919446
ABCB1decreases activityEXP 6480464CTDTacrolimus results in decreased activity of ABCB1 proteinPMID:20080907
ABCB1increases exportEXP 6480464CTDABCB1 protein results in increased export of TacrolimusPMID:11920757
ABCB1increases response to substanceEXP 6480464CTDABCB1 gene SNP results in increased susceptibility to TacrolimusPMID:12352921
ABCB1multiple interactionsEXP 6480464CTD[Tacrolimus binds to ABCB1 protein] inhibits the reaction [azidoprazosin binds to ABCB1 protein]; [Tacrolimus results in decreased activity of ABCB1 protein] which results in decreased export of Dexamethasone; Verapamil affects the reaction [ABCB1 protein results in increased export of Tacrolimus]PMID:11920757 PMID:1381629 PMID:20080907
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