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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730823
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB1affects response to substanceEXP 6480464CTDABCB1 gene polymorphism affects the susceptibility to Methotrexate; ABCB1 gene SNP affects the susceptibility to MethotrexatePMID:16321374 PMID:18381794 PMID:22104130 PMID:22859359 PMID:25007187
ABCB1increases expressionEXP 6480464CTDMethotrexate results in increased expression of ABCB1 mRNA; Methotrexate results in increased expression of ABCB1 proteinPMID:15239124 PMID:17982279 PMID:24736981
ABCB1increases response to substanceEXP 6480464CTDABCB1 polymorphism results in increased susceptibility to MethotrexatePMID:21887680
ABCB1multiple interactionsEXP 6480464CTDABCB1 gene polymorphism affects the reaction [Methotrexate results in decreased secretion of IFNG protein]; ABCB1 gene polymorphism affects the reaction [Methotrexate results in decreased secretion of IL2 protein]; ABCB1 gene polymorphism affects the reaction [Methotrexate results in decreased secretion of TNF protein]; ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein affects the susceptibility to [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA]PMID:12576456 PMID:16321374 PMID:16932953 PMID:17982279
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