GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ABCB1 | affects response to substance | EXP | | 6480464 | CTD | ABCB1 gene polymorphism affects the susceptibility to Methotrexate; ABCB1 gene SNP affects the susceptibility to Methotrexate | PMID:16321374 PMID:18381794 PMID:22104130 PMID:22859359 PMID:25007187 | ABCB1 | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of ABCB1 mRNA; Methotrexate results in increased expression of ABCB1 protein | PMID:15239124 PMID:17982279 PMID:24736981 | ABCB1 | increases response to substance | EXP | | 6480464 | CTD | ABCB1 polymorphism results in increased susceptibility to Methotrexate | PMID:21887680 | ABCB1 | multiple interactions | EXP | | 6480464 | CTD | ABCB1 gene polymorphism affects the reaction [Methotrexate results in decreased secretion of IFNG protein]; ABCB1 gene polymorphism affects the reaction [Methotrexate results in decreased secretion of IL2 protein]; ABCB1 gene polymorphism affects the reaction [Methotrexate results in decreased secretion of TNF protein]; ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein affects the susceptibility to [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA] | PMID:12576456 PMID:16321374 PMID:16932953 PMID:17982279 | |
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