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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730823
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB1
Name: ATP binding cassette subfamily B member 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB1multiple interactionsEXP 6480464CTDcobaltous chloride promotes the reaction [HIF1A protein results in increased expression of ABCB1 mRNA]; HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of ABCB1 mRNA]]; zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ABCB1 mRNA]PMID:19128456 PMID:19714248
ABCB1decreases expressionISOAbcb1a (Rattus norvegicus)6480464CTDcobaltous chloride results in decreased expression of ABCB1A mRNAPMID:24386269
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