GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp2 | increases activity | EXP | | 6480464 | CTD | Thioacetamide results in increased activity of MMP2 protein | PMID:16511523 | Mmp2 | increases expression | EXP | | 6480464 | CTD | Thioacetamide results in increased expression of MMP2 mRNA | PMID:18395095 PMID:23408952 | Mmp2 | multiple interactions | EXP | | 6480464 | CTD | [Ethanol co-treated with Thioacetamide] results in increased expression of MMP2 mRNA; [Thioacetamide co-treated with Ethanol] results in increased expression of MMP2 protein; CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP2 mRNA]; KRT18 protein affects the reaction [Thioacetamide results in increased expression of MMP2 mRNA]; POMC protein alternative form promotes the reaction [Thioacetamide results in increased activity of MMP2 protein]; SPARC protein affects the reaction [Thioacetamide results in increased expression of MMP2 mRNA] | PMID:16511523 PMID:16780996 PMID:18395095 PMID:21863215 PMID:23408952 | Mmp2 | increases activity | ISO | Mmp2 (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased activity of MMP2 protein | PMID:17050028 PMID:30883860 | Mmp2 | increases expression | ISO | Mmp2 (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased expression of MMP2 mRNA; Thioacetamide results in increased expression of MMP2 protein | PMID:15095483 PMID:26957569 | Mmp2 | increases secretion | ISO | Mmp2 (Rattus norvegicus) | 6480464 | CTD | Thioacetamide results in increased secretion of MMP2 protein | PMID:22899499 | Mmp2 | multiple interactions | ISO | Mmp2 (Rattus norvegicus) | 6480464 | CTD | [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA; Iron, Dietary affects the reaction [Thioacetamide affects the expression of MMP2 mRNA]; rebaudioside A inhibits the reaction [Thioacetamide results in increased activity of MMP2 protein]; Sirolimus inhibits the reaction [Thioacetamide results in increased activity of MMP2 protein] | PMID:17050028 PMID:18032466 PMID:23830814 PMID:30883860 | | ||||||||||||||||||||||
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