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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2affects expressionEXP 6480464CTDDiethylhexyl Phthalate affects the expression of MMP2 proteinPMID:37406783
Mmp2decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of MMP2 mRNAPMID:32619501
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of MMP2 proteinPMID:31163220
Mmp2increases expressionISOMmp2 (Rattus norvegicus)6480464CTDDiethylhexyl Phthalate results in increased expression of MMP2 mRNAPMID:20920545
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of MMP2 mRNA; Diethylhexyl Phthalate results in increased expression of MMP2 proteinPMID:19956873
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA]; fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein]PMID:19956873
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