Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of MMP2 mRNAPMID:17997286
Mmp2multiple interactionsEXP 6480464CTDSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of MMP2 mRNA]PMID:17997286
Mmp2decreases activityISOMmp2 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in decreased activity of MMP2 proteinPMID:16934674
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of MMP2 mRNAPMID:30231594 PMID:31586451
Mmp2increases secretionISOMMP2 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased secretion of MMP2 proteinPMID:15531749
Mmp2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]PMID:16934674
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDanagliptin inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP2 mRNA]; loliolide inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP2 mRNA]PMID:30231594 PMID:31586451
Go Back to source page   Continue to Ontology report