Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2increases expressionEXP 6480464CTDNicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 proteinPMID:14569062 PMID:17151781 PMID:18986645 PMID:23825647
MMP2multiple interactionsEXP 6480464CTDlipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]PMID:18986645
MMP2decreases expressionISOMmp2 (Rattus norvegicus)6480464CTDNicotine results in decreased expression of MMP2 mRNAPMID:34153408
MMP2decreases expressionISOMmp2 (Mus musculus)6480464CTDNicotine results in decreased expression of MMP2 proteinPMID:20448088
MMP2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNAPMID:33091441
Go Back to source page   Continue to Ontology report