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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2decreases expressionEXP 6480464CTDthymoquinone results in decreased expression of MMP2 proteinPMID:32112862
MMP2multiple interactionsEXP 6480464CTDCTNNB1 protein inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; thymoquinone results in decreased expression of and results in decreased activity of MMP2 proteinPMID:27060453 PMID:32112862
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