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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f1
Name: E2F transcription factor 1
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f1decreases expressionEXP 6480464CTDUrsodeoxycholic Acid results in decreased expression of E2F1 proteinPMID:15222754
E2f1multiple interactionsEXP 6480464CTDNR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]PMID:14514686 PMID:15222754
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