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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f1
Name: E2F transcription factor 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f1increases expressionISOE2F1 (Homo sapiens)6480464CTDNicotine results in increased expression of E2F1 proteinPMID:20061081
E2f1multiple interactionsISOE2F1 (Homo sapiens)6480464CTDMK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]PMID:16601104 PMID:16862215 PMID:20061081
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