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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2decreases expressionEXP 6480464CTDGlucose results in decreased expression of ACE2 mRNAPMID:29211853
Ace2multiple interactionsEXP 6480464CTDNFE2L2 protein affects the reaction [Glucose results in decreased expression of ACE2 mRNA]; oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of ACE2 mRNA]]; trigonelline inhibits the reaction [Glucose results in decreased expression of ACE2 mRNA]PMID:29211853
Ace2decreases expressionISOAce2 (Mus musculus)6480464CTDGlucose results in decreased expression of ACE2 proteinPMID:29266779
Ace2multiple interactionsISOAce2 (Mus musculus)6480464CTDCEBPB protein inhibits the reaction [Glucose results in decreased expression of ACE2 protein]; Glucose inhibits the reaction [CEBPB protein binds to ACE2 promoter]; Valsartan inhibits the reaction [Glucose results in decreased expression of ACE2 protein]PMID:29266779
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