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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: CHEBI:3380
Term: captopril
Definition: A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.
Chemical ID: MESH:D002216
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2multiple interactionsEXP 6480464CTDCaptopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]PMID:31629013
Ace2decreases response to substanceISOACE2 (Homo sapiens)6480464CTDACE2 gene SNP results in decreased susceptibility to CaptoprilPMID:17473847
Ace2multiple interactionsISOAce2 (Mus musculus)6480464CTDCaptopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]PMID:33007385
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