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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727960
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hax1
Name: HCLS1 associated protein X-1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hax1affects localizationEXP 6480464CTDDoxorubicin affects the localization of HAX1 proteinPMID:31570982
Hax1multiple interactionsEXP 6480464CTDDoxorubicin affects the reaction [MIRLET7F-2 mRNA affects the localization of HAX1 protein]; MIRLET7F-2 mRNA affects the reaction [Doxorubicin affects the localization of HAX1 protein]; XPO1 protein inhibits the reaction [Doxorubicin affects the localization of HAX1 protein]PMID:31570982
Hax1decreases expressionISOHax1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of HAX1 proteinPMID:32068018
Hax1increases expressionISOHAX1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of HAX1 mRNAPMID:29803840
Hax1multiple interactionsISOHax1 (Mus musculus)6480464CTDNanotubes, Carbon inhibits the reaction [Doxorubicin results in decreased expression of HAX1 protein]PMID:32068018
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