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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727948
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1b
Name: PPARG coactivator 1 beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1bincreases expressionEXP 6480464CTDbisphenol A results in increased expression of PPARGC1B mRNAPMID:25181051
Ppargc1bdecreases methylationISOPPARGC1B (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of PPARGC1B genePMID:31601247
Ppargc1bincreases expressionISOPpargc1b (Mus musculus)6480464CTDbisphenol A results in increased expression of PPARGC1B mRNAPMID:26063408 PMID:32156529
Ppargc1bincreases expressionISOPPARGC1B (Homo sapiens)6480464CTDbisphenol A results in increased expression of PPARGC1B mRNAPMID:36828454
Ppargc1bmultiple interactionsISOPpargc1b (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PPARGC1B mRNAPMID:28433925
Ppargc1bmultiple interactionsISOPPARGC1B (Homo sapiens)6480464CTD[bisphenol A co-treated with Tamoxifen] results in increased expression of PPARGC1B mRNA; bisphenol A affects the reaction [Tamoxifen affects the expression of PPARGC1B mRNA]PMID:30467747
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