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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727915
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Acc ID: CHEBI:81014
Term: 3beta-hydroxycholest-5-en-26-oic acid
Definition: A steroid acid resulting from the oxidation of one of the terminal methyl groups of cholesterol to the corresponding aldehyde.
Chemical ID: MESH:C029435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp27a1increases chemical synthesisISOCYP27A1 (Homo sapiens)6480464CTDCYP27A1 protein results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acidPMID:14622972
Cyp27a1multiple interactionsISOCYP27A1 (Homo sapiens)6480464CTD[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acidPMID:8078928 PMID:9215552 PMID:9660774
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