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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects activityEXP 6480464CTDMethylnitrosourea affects the activity of RELA proteinPMID:16098260
Relaaffects localizationEXP 6480464CTDMethylnitrosourea affects the localization of RELA proteinPMID:15960898
Reladecreases expressionEXP 6480464CTDMethylnitrosourea results in decreased expression of RELA protein; Methylnitrosourea results in decreased expression of RELA protein modified formPMID:16762860 PMID:17137578
Relaincreases expressionEXP 6480464CTDMethylnitrosourea results in increased expression of RELA proteinPMID:16098260
Relamultiple interactionsEXP 6480464CTD3-aminobenzamide inhibits the reaction [Methylnitrosourea results in decreased expression of RELA protein modified form]; [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]PMID:15960898 PMID:16098260 PMID:17137578
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