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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDOkadaic Acid results in increased phosphorylation of RELA proteinPMID:11591705
Relaincreases phosphorylationISORela (Mus musculus)6480464CTDOkadaic Acid results in increased phosphorylation of RELA proteinPMID:27050422
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDanethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; Fenretinide inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; Okadaic Acid inhibits the reaction [IL1B protein results in decreased phosphorylation of RELA protein]; Okadaic Acid inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid results in increased expression of and affects the localization of RELA protein; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; zerumbone inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]PMID:10871845 PMID:11591705 PMID:15090542 PMID:15322087 PMID:15710601 PMID:16007145 PMID:16230421 PMID:35577138 PMID:9973483
Relamultiple interactionsISORela (Mus musculus)6480464CTD[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid] results in increased expression of RELA protein; Quercetin inhibits the reaction [Okadaic Acid results in increased phosphorylation of RELA protein]PMID:27050422 PMID:33069748
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