GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rela | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of RELA protein | PMID:21296072 PMID:23082119 PMID:24223152 | Rela | multiple interactions | EXP | | 6480464 | CTD | [[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of RELA protein; [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of RELA protein; [Oxygen deficiency co-treated with Oxygen] results in increased expression of and affects the localization of RELA protein; [Oxygen deficiency co-treated with Oxygen] results in increased expression of RELA mRNA; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]; cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased localization of and results in increased activity of RELA protein]; Lipopolysaccharides promotes the reaction [Oxygen deficiency results in increased expression of RELA protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]; Oxygen deficiency results in increased localization of and results in increased activity of RELA protein; prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides promotes the reaction [Oxygen deficiency results in increased expression of RELA protein]]; prolinedithiocarbamate inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]; resveratrol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of RELA protein]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of and affects the localization of RELA protein]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of RELA mRNA] | PMID:18635243 PMID:21296072 PMID:23082119 PMID:24223152 PMID:25322861 PMID:27064547 | Rela | affects localization | ISO | RELA (Homo sapiens) | 6480464 | CTD | Oxygen affects the localization of RELA protein; Oxygen deficiency affects the localization of RELA protein | PMID:11034997 PMID:17468103 PMID:21926265 PMID:23452621 | Rela | affects localization | ISO | Rela (Mus musculus) | 6480464 | CTD | Oxygen deficiency affects the localization of RELA protein modified form | PMID:24223152 | Rela | affects response to substance | ISO | RELA (Homo sapiens) | 6480464 | CTD | RELA protein affects the susceptibility to Oxygen deficiency | PMID:17671207 | Rela | increases activity | ISO | Rela (Mus musculus) | 6480464 | CTD | Oxygen results in increased activity of RELA protein | PMID:30529165 | Rela | increases expression | ISO | RELA (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of RELA mRNA; Oxygen deficiency results in increased expression of RELA protein | PMID:23452621 PMID:29685624 PMID:29966676 | Rela | increases expression | ISO | Rela (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of RELA protein | PMID:24223152 | Rela | multiple interactions | ISO | RELA (Homo sapiens) | 6480464 | CTD | 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; 3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased localization of RELA protein]; [Ozone co-treated with Oxygen] results in increased localization of RELA protein; AG 1879 inhibits the reaction [Oxygen deficiency promotes the reaction [NFKB1 protein binds to RELA protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]; Genistein inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [RELA protein affects the susceptibility to Oxygen deficiency]; Oxygen deficiency promotes the reaction [NFKB1 protein binds to RELA protein]; Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]; Plant Extracts inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Resveratrol inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Rosiglitazone inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Rotenone inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]] | PMID:11950692 PMID:17671207 PMID:21926265 PMID:23452621 PMID:26270818 PMID:29685624 | Rela | multiple interactions | ISO | Rela (Mus musculus) | 6480464 | CTD | [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased acetylation of RELA protein; [CBS gene mutant form results in increased susceptibility to [Blood Glucose deficiency co-treated with Oxygen deficiency]] which results in increased acetylation of RELA protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of and affects the localization of RELA protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of RELA protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of RELA protein; [Quercetin co-treated with Oxygen] results in decreased expression of RELA protein; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of RELA protein modified form]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein]; NFE2L2 protein affects the reaction [Oxygen results in increased activity of RELA protein]; NFE2L2 protein affects the reaction [sulforaphane inhibits the reaction [Oxygen results in increased activity of RELA protein]]; Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of RELA protein]; prolinedithiocarbamate inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of RELA protein]; RELA protein modified form promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form]; RELA protein promotes the reaction [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC11A2 mRNA alternative form]; sodium bisulfide inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased acetylation of RELA protein]; sulforaphane inhibits the reaction [Oxygen results in increased activity of RELA protein] | PMID:16395278 PMID:21925195 PMID:22666436 PMID:24223152 PMID:29432836 PMID:30529165 PMID:31283913 | | ||||||||||||||||||||||
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