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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:1367
Term: 3,3',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.
Chemical ID: MESH:C028451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases expressionISORELA (Homo sapiens)6480464CTD3,4,3',4'-tetrachlorobiphenyl results in increased expression of RELA mRNAPMID:26519613
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ESR1 protein binds to RELA promoter]; 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [KDM4B protein binds to RELA promoter]; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of and affects the localization of RELA protein; KDM4B protein promotes the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of RELA mRNA]PMID:26519613
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