GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsdme | affects response to substance | ISO | GSDME (Homo sapiens) | 6480464 | CTD | DFNA5 protein affects the susceptibility to artenimol | PMID:33689708 | Gsdme | increases cleavage | ISO | GSDME (Homo sapiens) | 6480464 | CTD | artenimol results in increased cleavage of GSDME protein | PMID:34655567 | Gsdme | increases expression | ISO | GSDME (Homo sapiens) | 6480464 | CTD | artenimol results in increased expression of DFNA5 mRNA; artenimol results in increased expression of DFNA5 protein; artenimol results in increased expression of DFNA5 protein alternative form | PMID:33689708 | Gsdme | multiple interactions | ISO | GSDME (Homo sapiens) | 6480464 | CTD | acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [artenimol results in increased cleavage of GSDME protein]; AIM2 protein affects the reaction [artenimol results in increased expression of DFNA5 protein alternative form]; AIM2 protein affects the reaction [artenimol results in increased expression of DFNA5 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [artenimol results in increased cleavage of GSDME protein]; DFNA5 protein affects the reaction [artenimol results in increased expression of HMGB1 protein]; DFNA5 protein affects the reaction [artenimol results in increased secretion of IL18 protein]; DFNA5 protein affects the reaction [artenimol results in increased secretion of IL1B protein]; GSDME protein affects the reaction [artenimol results in increased cleavage of CASP3 protein]; GSDME protein affects the reaction [artenimol results in increased expression of IL1B protein]; GSDME protein affects the reaction [artenimol results in increased secretion of IL18 protein]; GSDME protein affects the reaction [artenimol results in increased secretion of IL1B protein]; PKM protein inhibits the reaction [artenimol results in increased cleavage of GSDME protein] | PMID:33689708 PMID:34655567 | | ||||||||||||||||||||||
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