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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727850
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kiss1
Name: KiSS-1 metastasis-suppressor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kiss1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of KISS1 mRNA; bisphenol A results in decreased expression of KISS1 proteinPMID:19106226 PMID:19442818 PMID:22101008 PMID:25181051
Kiss1increases expressionEXP 6480464CTDbisphenol A results in increased expression of KISS1 mRNAPMID:33967032 PMID:35429613 PMID:35567931
Kiss1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of KISS1 genePMID:28505145
Kiss1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of KISS1 genePMID:28505145
Kiss1decreases expressionISOKiss1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of KISS1 mRNA; bisphenol A results in decreased expression of KISS1 proteinPMID:32407858
Kiss1increases abundanceISOKiss1 (Mus musculus)6480464CTDbisphenol A results in increased abundance of KISS1 protein modified formPMID:36508816
Kiss1increases cleavageISOKiss1 (Mus musculus)6480464CTDbisphenol A results in increased cleavage of KISS1 proteinPMID:36508816
Kiss1increases expressionISOKiss1 (Mus musculus)6480464CTDbisphenol A results in increased expression of KISS1 mRNA; bisphenol A results in increased expression of KISS1 proteinPMID:21182934 PMID:24403293 PMID:24532816 PMID:27641926
Kiss1multiple interactionsISOKISS1 (Homo sapiens)6480464CTD[[Environmental Pollutants results in increased abundance of Phenols] which results in increased abundance of bisphenol A] which results in decreased methylation of KISS1 genePMID:36657687
Kiss1multiple interactionsISOKiss1 (Mus musculus)6480464CTD[bisphenol A results in increased cleavage of KISS1 protein] which results in increased abundance of KISS1 protein modified form; bisphenol A promotes the reaction [Estradiol results in increased expression of KISS1 mRNA]; KISS1 protein inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; KISS1 protein inhibits the reaction [bisphenol A results in decreased expression of LHB protein]PMID:24532816 PMID:32407858 PMID:36508816
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