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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727785
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smyd2
Name: SET and MYND domain containing 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smyd2multiple interactionsISOSmyd2 (Mus musculus)6480464CTD[SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of IL6 mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of TNF mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of CD36 mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of MARCO mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of MMP9 mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of MSR1 mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of SCARB1 mRNA; SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]PMID:29718165
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