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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3increases expressionEXP 6480464CTDoltipraz results in increased expression of ABCC3 mRNA; oltipraz results in increased expression of ABCC3 proteinPMID:12920174
Abcc3multiple interactionsEXP 6480464CTD[oltipraz results in increased expression of ABCC3 protein] which affects the export of Acetaminophen metabolitePMID:12920174
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDoltipraz results in increased expression of ABCC3 mRNAPMID:16837569
Abcc3increases expressionISOAbcc3 (Mus musculus)6480464CTDoltipraz results in increased expression of ABCC3 mRNAPMID:15833929 PMID:22496397 PMID:30114225
Abcc3multiple interactionsISOAbcc3 (Mus musculus)6480464CTD[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA]PMID:15833929 PMID:22496397 PMID:30114225
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