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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3affects expressionISOABCC3 (Homo sapiens)6480464CTDMethotrexate affects the expression of ABCC3 mRNAPMID:23897011
Abcc3affects response to substanceISOABCC3 (Homo sapiens)6480464CTDABCC3 gene mutant form affects the susceptibility to Methotrexate; ABCC3 gene SNP affects the susceptibility to MethotrexatePMID:19426680 PMID:22859359
Abcc3decreases response to substanceISOAbcc3 (Mus musculus)6480464CTDABCC3 mRNA results in decreased susceptibility to MethotrexatePMID:16918715
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