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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3decreases expressionISOAbcc3 (Mus musculus)6480464CTDLithocholic Acid results in decreased expression of ABCC3 mRNAPMID:25582706
Abcc3increases activityISOABCC3 (Homo sapiens)6480464CTDLithocholic Acid results in increased activity of ABCC3 proteinPMID:14570758
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDLithocholic Acid results in increased expression of ABCC3 mRNAPMID:14570758 PMID:20888898 PMID:25055961
Abcc3increases expressionISOAbcc3 (Mus musculus)6480464CTDLithocholic Acid results in increased expression of ABCC3 mRNA; Lithocholic Acid results in increased expression of ABCC3 proteinPMID:15358766 PMID:15824121 PMID:16436656 PMID:20977460
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTD[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNAPMID:14570758
Abcc3multiple interactionsISOAbcc3 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC3 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]PMID:15358766 PMID:18032408 PMID:20977460
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