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GENE - TERM ANNOTATION REPORT

RGD ID: 71069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fcgr2a
Name: Fc gamma receptor 2A
Acc ID: GO:0006911
Term: phagocytosis, engulfment
Definition: The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Definition Source(s): GOC:curators, ISBN:0781735149
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fcgr2aacts_upstream_of_or_withinISOFcgr3 (Mus musculus)1624291RGDMGI:1861924 PMID:8769481 PMID:9743367 PMID:9834201

PMID:8769481 PMID:9743367 PMID:9834201
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