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GENE - TERM ANNOTATION REPORT

RGD ID: 71069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fcgr2a
Name: Fc gamma receptor 2A
Acc ID: DOID:12365
Term: malaria
Definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Malaria "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=malaria "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fcgr2a ISOFCGR2A (Homo sapiens)5147921RGDDNA:missense mutation:cds:p.H131R (human) 
Fcgr2asusceptibilityISOFCGR2A (Homo sapiens)7240710OMIM  
Fcgr2a ISOFCGR2A (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Fcgr2a ISOFCGR2A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Malaria, severe, susceptibility toPMID:10675363 PMID:15367919 PMID:19915573 PMID:19965803 PMID:24033266 PMID:8636449 PMID:9843982
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