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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk12
Name: mitogen-activated protein kinase 12
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7317166480464CTDMAPK12 protein affects the susceptibility to Etoposide

PMID:21878638
increases activityISORGD:7317166480464CTDEtoposide results in increased activity of MAPK12 protein

PMID:21878638
multiple interactionsISORGD:7317166480464CTD[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide, [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide

PMID:21878638
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.