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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk12
Name: mitogen-activated protein kinase 12
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7317166480464CTDCadmium Chloride results in decreased expression of MAPK12 protein

PMID:19757093
increases expressionISORGD:7317166480464CTDCadmium Chloride results in increased expression of MAPK12 mRNA

PMID:19757093
multiple interactionsISORGD:7359686480464CTDMAPK12 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]], MAPK12 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]

PMID:18348256
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.