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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70971
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hamp
Name: hepcidin antimicrobial peptide
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hampdecreases expressionISOHamp (Mus musculus)6480464CTDHeparin results in decreased expression of HAMP mRNAPMID:25686467
Hampdecreases expressionISOHAMP (Homo sapiens)6480464CTDHeparin results in decreased expression of HAMP mRNAPMID:25633564 PMID:25686467
Hampdecreases secretionISOHAMP (Homo sapiens)6480464CTDHeparin results in decreased secretion of HAMP protein modified formPMID:25633564
Hampmultiple interactionsISOHAMP (Homo sapiens)6480464CTDHeparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]PMID:25633564
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