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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70936
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col18a1
Name: collagen type XVIII alpha 1 chain
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col18a1decreases expressionEXP 6480464CTDcobaltous chloride results in decreased expression of COL18A1 mRNAPMID:24386269
Col18a1decreases expressionISOCOL18A1 (Homo sapiens)6480464CTDcobaltous chloride results in decreased expression of COL18A1 mRNA; cobaltous chloride results in decreased expression of COL18A1 proteinPMID:13679210
Col18a1multiple interactionsISOCOL18A1 (Homo sapiens)6480464CTD[cobaltous chloride results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of COL18A1 mRNA; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]PMID:13679210
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