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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70896
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ces1d
Name: carboxylesterase 1D
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ces1daffects bindingISOCES1 (Homo sapiens)6480464CTDCocaine binds to CES1 proteinPMID:9311626
Ces1dincreases hydrolysisISOCES1 (Homo sapiens)6480464CTDCES1 protein results in increased hydrolysis of CocainePMID:12679808 PMID:12773168 PMID:25445008 PMID:9311626
Ces1dmultiple interactionsISOCES1 (Homo sapiens)6480464CTDCES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol]; Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]PMID:12773168 PMID:8930175 PMID:9311626
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